As the Group continued to target, 1st Lieutenant C. Floyd Edwards, pilot of Ramp Tramp⇗, had been hit in the leg by an enemy fighter. 2nd Lieutenant Paul Pate Gordy (Co-Pilot) took over the controls, completing the bomb run and maintaining formation to get the crew safely home.

As the Group reached the target area, a heavy smoke screen was encountered over Hamburg. 1st Lieutenant Michael A. Smithwick (Lead Bombardier) noted in the bombardier's report⇗: "There was a heavy billowy smoke screen in effect over the target area, however, landmarks were still visible. The turn on target was made on a magnetic heading of 248 actual which was not as briefed... Results of the bombing were unobserved because of the heavy smoke screen." 

11 aircraft successfully completed the bombing run.

After bombs were dropped on target, initial fears arose that they had been dropped on "safe" due to faulty arming wires. However, a follow-up investigation by Captain Charles D. Bonnett (Station Bombardier) later confirmed that the bombs had properly armed before release. 

Another interesting note from the Mission Armament Report⇗ was by 1st Lieutenant H. R. Kircher (Group Armament Officer). He noted that 60,900 rounds of ammunition had been fired at enemy fighters by the aircraft that made it back to base; with the grand total of ammunition fired being 145,900 rounds when factoring in the lost aircraft too. 

The cost of Mission #10 was severe, with seven aircraft failing to return to base. 

Shortly before reaching the initial point, Passes Cancelled⇗, piloted by 2nd Lt. Gordon Hankinson, was disabled by enemy aircraft, fell into a flat spin, and crashed near Hamburg, Germany. Wounded crew members included Hankinson, 2nd Lt. Edwin Halseth (Co-Pilot), S/Sgt. David Kay (Radio Operator), S/Sgt. Robert Burnes (Engineer/Top Turret Gunner), and S/Sgt. Frank Delmonte (Ball Turret Gunner). All ten crew members bailed out, survived, and were taken as prisoners of war.

In the lower squadron, Thundermug⇗, piloted by 2nd Lt. Kelmer J. Hall took intense enemy fire. 2nd Lt. Bradley Summers (Co-Pilot) recalled in Ken Decker’s book, Memories of the 384th Bombardment Group: "When you’d see ‘em flying at you [the 20 mm rounds], you could pull back on the wheel a little bit and it was kind of interesting to see these explosive shells come popping right through underneath right where we had been... just 'pop, pop, pop' even in spaces, little puffs of smoke." T/Sgt. Kenny Harland (Top Turret Engineer) remained at his post despite shattered glass and splinter wounds, while Sgt. George McCulley (Tail Gunner) was blown from his seat twice by concussions before his weapons were knocked out. When elevator control was shot away completely, 2nd Lt. Kelmer J. Hall signaled for the crew to jump: "the stick just came right back in our laps and the nose came up on that plane... K.J. pulled the power off and he grabbed my parachute strap on my shoulder and gave it a big tug... He pointed down at the escape hatch... and the escape hatch was gone." Sgt. Kenneth Harland (Engineer/Top Turret Gunner) and Sgt. Holgate Dean (Waist Gunner) were killed in action; the eight surviving crew members were taken prisoners of war.